2. Signaling Pathways
  3. GPCR/G Protein
  4. Prostaglandin Receptor

Prostaglandin Receptor

Prostaglandin Receptor

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Prostaglandin receptor, a sub-family of cell surface seven-transmembrane receptors, are the G-protein-coupled receptors. There are currently ten known prostaglandin receptors on various cell types. Prostaglandins bind to a subfamily of cell surface seven-transmembrane receptors, G-protein-coupled receptors. These receptors are named: DP1-2-DP1, DP2 receptors, EP1-4-EP1, EP2, EP3, EP4 receptors, FP-FP, IP1-2-IP1, IP2 receptors, TP-TP receptor. The prostaglandins are a group of hormone-like lipid compounds that are derived enzymatically from fatty acids and have important functions in the animalbody. There are currently ten known prostaglandin receptors on various cell types.

Prostaglandin Receptor Isoform Specific Products:

Prostaglandin Receptor Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-108564
    L 655240
    		Antagonist
    L 655240 is thromboxane antagonist. L 655240 attenuates early ischemia- and reperfusion-induced arrhythmias in a canine model of coronary artery occlusion. L 655240 also involves in cancer and autoimmune disorders.
    L 655240
  • HY-19641
    AH13205
    		Agonist
    AH13205 is a selective prostanoid EP2-receptor agonist. AH13205 causes concentration-related relaxations of Carbachol (HY-B1208)-contracted trachea. AH13205 causes dose-related protection against Histamine (HY-B1204)-induced increases in respiratory rate.
    AH13205
  • HY-169803
    L-657926
    L-657926 is a stereoselective antagonist of the thromboxane A2 (TxA2) receptor, composed of (-)-9-chlorobenzyl-6-fluoro-1,2,3,4-tetrahydrocarbazol-1-yl acetic acid and (+)-9-chlorobenzyl-6-fluoro-1,2,3,4-tetrahydrocarbazol-l-yl acetic acid. The IC50s of (-) and (+) configurations for TxA2 are 0.27 nM and 124 nM, respectively.
    L-657926
  • HY-182513
    ONO-8539
    		Antagonist
    ONO-8539 is an orally active prostanoid EP1 receptor antagonist with competitive, insurmountable binding and slow receptor dissociation for long-duration inhibition. ONO-8539 modulates afferent nerve function related to bladder activity, inhibits detrusor overactivity-related contractions, decreases nonvoiding contractions and voiding duration, and increases uroflow rate with ATP (HY-B2176)-induced detrusor overactivity. ONO-8539 attenuates acid-induced heartburn symptoms, extends time to first heartburn sensation, and prevents primary hypersensitivity after distal esophageal acidification. ONO-8539 can be used for the research of overactive bladder and gastroesophageal reflux disease.
    ONO-8539
  • HY-118163
    tetranor-PGFM
    		Control
    tetranor-PGFM is the major urinary metabolite of Dinoprost (HY-12956).
    tetranor-PGFM
  • HY-137574
    19(R)-Hydroxy prostaglandin E1
    		Agonist
    19(R)-Hydroxy prostaglandin E1 (19(R)-Hydroxy PGE1), the major prostaglandin in primate semen, is an agonist of EP1 and EP3 receptor subtypes and exhibits contractile activity on smooth muscle preparations.
    19(R)-Hydroxy prostaglandin E1
  • HY-134135
    Prostaglandin A1 methyl ester
    Prostaglandin A1 methyl ester (PGA1 methyl ester) is a cyclopentenone analog.
    Prostaglandin A1 methyl ester
  • HY-105126
    Rioprostil
    		Control
    Rioprostil (TR4698) is an orally effective analogue of prostaglandin E1, possessing potent antisecretory and anti-gastric lesion properties. Rioprostil can be utilized in mucosal protection research.
    Rioprostil
  • HY-19255
    FK-788
    		Agonist
    FK-788 is a PGI(2) and IP agonist with a strong anti-aggregation effect, with an IC50 of 18 nM and a high binding affinity for the human recombinant IP receptor, with a Ki value of 20 nM.
    FK-788
  • HY-108560R
    (+)-Fluprostenol (Standard)
    		Activator
    (+)-Fluprostenol (Standard) is the analytical standard of (+)-Fluprostenol. This product is intended for research and analytical applications. (+)-Fluprostenol is a potent agonist of PTGER2. (+)-Fluprostenol decreases the expression of Oviductal glycoprotein 1 (OVGP1).
    (+)-Fluprostenol (Standard)
  • HY-A0195R
    Carboprost tromethamine (Standard)
    Carboprost (tromethamine) (Standard) is the analytical standard of Carboprost (tromethamine). This product is intended for research and analytical applications. Carboprost tromethamine is the synthetic 15-methyl analogue of prostaglandin F2α. Carboprost tromethamine can effectively promote law contraction of the uterus and significantly reduce the amount of bleeding during and after delivery.
    Carboprost tromethamine (Standard)
  • HY-118754
    13,14-Dihydro-15-keto PGF1α
    13,14-Dihydro-15-keto PGF1α is a metabolite of PGF1α.
    13,14-Dihydro-15-keto PGF1α
  • HY-131664
    EP3 antagonist 2
    		Antagonist
    EP3 antagonist 2 (Compound Exp 1) is a potent and selective EP3 receptor antagonist. EP3 antagonist 2 has a strong binding affinity for the human EP3 receptor (Ki: 3.3 nM) and significant antagonistic activity (IC50: 30.8 nM, determined by cellular cAMP levels).
    EP3 antagonist 2
  • HY-116281
    ICI D1542
    		Inhibitor
    ICI D1542 is a selective and potent inhibitor of thromboxane A2 (TXA2) synthase and the thromboxane A2 receptor (TP-receptor). ICI D1542 is effective at preventing thrombus formation by redirection of arachidonic acid metabolism.
    ICI D1542
  • HY-123328
    AGN 191976
    		Agonist
    AGN 191976 is a potent and selective thromboxane A2-sensitive (TP) receptor agonist with EC50 values ​​of 0.23 nM and 24 nM in rat aorta and human platelets, respectively. AGN 191976 has potent IOP-lowering effects in dogs and monkeys. AGN 191976 can be used to study vascular biology and the role of thromboxane A2 in vascular function.
    AGN 191976
  • HY-W588266
    Isopropyl 5-(diphenylphosphoryl)pentanoate
    		Control
    Isopropyl 5-(diphenylphosphoryl)pentanoate is the impurity of Latanoprost (HY-B0577).
    Isopropyl 5-(diphenylphosphoryl)pentanoate
  • HY-168382A
    5S(6R)-EET
    		Agonist
    5S(6R)-EET is the metabolite of Arachidonic acid (HY-109590). 5S(6R)-EET activates the synthesis of endogenous prostaglandin (PGE2), which inhibits the Na+ absorption, increases the intracellular Ca2+, and promotes the depolarization of transmembrane voltage. 5S(6R)-EET is more active than 5R(6S)-EET (HY-168382).
    5S(6R)-EET
  • HY-124175
    16-Phenoxy prostaglandin F2α ethyl amide
    16-Phenoxy prostaglandin F2α ethyl amide is a metabolically stable PGF2α analogue containing a acetamide structure.
    16-Phenoxy prostaglandin F2α ethyl amide
  • HY-108563AR
    SC 51089 free base (Standard)
    		Antagonist
    SC 51089 free base (Standard) is the analytical standard of SC 51089 (free base) (HY-108563A). This product is intended for research and analytical applications. SC 51089 free base is a selective antagonist of prostaglandin E2 EP1 receptor, with Kis of 1.3, 11.2, 17.5, and 61.1 μM for EP1, TP, EP3, and FP receptors, respectively. SC 51089 free base exhibits neuroprotective activity.
    SC 51089 free base (Standard)
  • HY-101840R
    EIPA (Standard)
    		Inhibitor
    EIPA (Standard) is the analytical standard of EIPA. This product is intended for research and analytical applications. EIPA (L593754) is an orally active TRPP3 channel inhibitor with an IC50 of 10.5 μM. EIPA also enhances autophagy by inhibiting Na+/H+-exchanger 3 (NHE3). EIPA inhibits macropinocytosis as well. EIPA can be used in the research of inflammation and cancers, such as gastric cancer, colon carcinoma, pancreatic carcinoma.
    EIPA (Standard)
Cat. No. Product Name / Synonyms Application Reactivity
Prostaglandin Receptor Isoform Comparison

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